| Abstrakt: |
Free‐radical copolymerization of N‐vinylpyrrolidone (VP) with tert‐butyl methacrylate (TBMA) was carried out in bulk at 50 °C, using 2,2′‐azobisisobutyronitrile as initiator. From copolymer composition determined by 1H‐NMR analysis and using the modified Kelen–Tüdos equation, the monomer reactivity ratios were determined. After acidic hydrolysis, the modification reaction of some N‐vinylpyrrolidone‐tert‐butyl methacrylate‐methacrylic acid (VP‐TBMA‐MAA) terpolymers with several model bioactive amino compounds (benzocaine, phenethylamine, tyramine) and a model amino sugar (2‐amino‐2‐deoxy‐D‐glucose (glucosamine)) was studied in the homogeneous phase. Interaction experiments between glucosamine‐carrying VP‐TBMA‐MAA terpolymers and Concanavalin A (Con A) in a phosphate buffer (pH = 7.2) at room temperature showed that VP‐TBMA‐MAA terpolymer interacts with Con A. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 18–27, 2005 |
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