| Autor: |
Chong, Ming Yao, Lorimer, Cressida F, Mehta, Shaveta, Ibrahim, Ehab, Brock, Juliet, McBain, Catherine, McLoone, Philip, Chalmers, Anthony J |
| Zdroj: |
CNS Oncology; December 2019, Vol. 8 Issue: 4 |
| Abstrakt: |
Aim:We investigated uptake of short-course chemo-radiotherapy and compared outcomes with other treatment schedules in elderly patients with glioblastoma (GBM). Methods:Patients aged 65 or over with a diagnosis of GBM were identified from an 18-month period from three centers in the UK. The primary end point of this study was overall survival from the date of diagnosis. Results:The analysis included 210 patients. Overall median survival was 5.0 months. Approximately 31.9% of patients received combined chemoradiation; multivariate analysis showed that patients who received standard chemoradiation were at a reduced risk of death than those receiving hypofractionated chemoradiation. Discussion:In this retrospective study, patients treated with standard chemoradiation experienced better outcomes than patients receiving hypofractionated chemoradiation. Patient selection likely contributed to these findings. |
| Databáze: |
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