Genetic links to congenital heart defects: A comprehensive meta-analysis of MTHFD1and CBSpolymorphisms

Autor: Bala, Ankush, Sudershan, Amrit, Kumar, Dharminder, Digra, Sanjeev K., Panjaliya, Rakesh K., Kumar, Parvinder
Zdroj: Human Gene; September 2024, Vol. 41 Issue: 1
Abstrakt: Congenital heart defects (CHD) emerge prominently as anomalies during the intricate process of fetal development, manifesting when the heart or adjacent blood vessels deviate from their customary developmental trajectory before birth. The prevailing hypothesis is that polymorphisms within two pivotal candidate genes, specifically MTHFD1G1958A and CBS844ins68, may contribute to an increased susceptibility to CHD.
Databáze: Supplemental Index