Evidence for the appearance of a reticulocyte population low in lipoxygenase mRNA during the recovery from a phenylhydrazine-induced anemia in rabbits

Autor: Minich, W.B., Evdokimova, V.M., Oleinikov, A.V., Höhne, M., Thiele, B.J., Rapoport, S.M.
Zdroj: FEBS Letters; January 1989, Vol. 245 Issue: 1 p127-130, 4p
Abstrakt: It is shown that during recovery from a phenylhydrazine-induced anemia in rabbits a selective decrease in lipoxygenase mRNA takes place with a corresponding shut-off of the synthesis of the enzyme. It is suggested that a new population, ‘recovery’-reticulocytes, makes its appearance in the peripheral blood. Their cells are more mature than the stress macroreticulocytes. A cell-free system prepared from the recovery-reticulocytes exhibits low endogenous synthesis of non-globin polypeptides, even without nuclease treatment, but retains full capacity to be stimulated by exogenous mRNA.
Databáze: Supplemental Index