| Autor: |
Nishida, Tsutomu, Nakai, Satoru, Kawakami, Takuma, Aihara, Koutoku, Nishino, Naoki, Hirai, Yoshikatsu |
| Zdroj: |
FEBS Letters; January 1989, Vol. 243 Issue: 1 p25-29, 5p |
| Abstrakt: |
BSF-2/IL-6, GM-CSF and IL-1β mRNAs were induced by recombinant IL-1 in human astrocytoma cell line U373MG. The induction of BSF-2/IL-6 and IL-1β mRNAs did not require de novo protein synthesis while that of GM-CSF mRNA required a newly synthesized protein. Dexamethasone inhibited the induction of these cytokine mRNAs by IL-1. This process seems to require continued protein synthesis. These results suggest that the production of these cytokines are positively and negatively controlled by IL-1 and glucocorticoids, respectively, in astrocytes. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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