| Autor: |
Szalay, Katalin Sz., Folly, Gábor |
| Zdroj: |
FEBS Letters; January 1992, Vol. 296 Issue: 1 p87-89, 3p |
| Abstrakt: |
The combined effects of ACTH, β-endorphin (β-EP) and α-MSH were studied on the corticosteroidogenesis or isolated rat adrenocortical zona fasciculata and zona glomerulosa cells. β-EP potentiated the effects of ACTH and α-MSH on the zona fasciculata corticosterone production but inhibited those on the zona glomerulosa aldosterone production. β-EP did not affect the combined action of 4×10 −11M ACTH and 5×10 −9M α-MSH on the zona fasciculata or the zona glomerulosa cells, but it inhibited the stimulatory action of the combination of 1.6×10 −10M ACTH and 10 −9M α-MSH on the zona glomerulosa aldosterone production. An interaction of ACTH, β-EP and α-MSH in relation to the zona fasciculata and zona glomerulosa corticosteroid production was found. |
| Databáze: |
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