| Autor: |
Quinn, Paul, Judah, Jacob D. |
| Zdroj: |
FEBS Letters; January 1990, Vol. 263 Issue: 2 p365-368, 4p |
| Abstrakt: |
We have investigated the effect of the weak base Tris on the processing and secretion of albumin and α-1 antitrypsin by hepatocytes in culture. We show that the secretion of both proteins is 90% inhibited by 30 mM Tris. The post-synthetic processing of both proteins is inhibited to the same extent. These effects are completely reversible. Cell fractionation indicates that albumin accumulates in the Golgi, whereas α-1 antitrypsin fails to leave the endoplasmic reticulum. |
| Databáze: |
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