| Autor: |
Loreau, Nadine, Boiziau, Claudine, Verspieren, Philippe, Shire, David, Toulmé, Jean-Jacques |
| Zdroj: |
FEBS Letters; January 1990, Vol. 274 Issue: 1 p53-56, 4p |
| Abstrakt: |
Synthetic oligodeoxynucleotides, either unmodified or linked to an intercalating agent, have been used to prevent cDNA elongation by the AMV reverse transcriptase. Oligonucleotide/RNA hybrids specifically arrest primer extension. The blockage involves the degradation of the RNA part bound to the antisense oligonucleotide by the RNase-H activity associated with the retroviral polymerase. |
| Databáze: |
Supplemental Index |
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