| Autor: |
Pape, P.C., Konishi, M., Baylor, S.M., Somlyo, A.P. |
| Zdroj: |
FEBS Letters; January 1988, Vol. 235 Issue: 1 p57-62, 6p |
| Abstrakt: |
Heparin, an inhibitor of inositol trisphosphate (InsP 3)-induced Ca 2+release in smooth muscle and non-muscle cells, was injected into intact frog skeletal muscle fibres. Ca 2+release from the sarcoplasmic reticulum was elicited by the normal action potential mechanism and monitored by both fura-2 fluorescence and an intrinsic birefringence signal. Both optical signals, and hence Ca 2+release, were unaffected by high concentrations of heparin. This result argues against a major physiological role of InsP 3as a chemical messenger of excitation-contraction coupling in skeletal muscle. |
| Databáze: |
Supplemental Index |
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