| Autor: |
Chen, Yongkang, Yang, Lei, Gao, Xiaofeng, Tang, Aolin, He, Hang, Xiong, Chengjie, Xu, Feng, Sun, Chao |
| Zdroj: |
Global Spine Journal; 20240101, Issue: Preprints |
| Abstrakt: |
Study Design Prospective cohort study.Objectives Diabetes mellitus (DM) is associated with unfavourable patient-reported outcomes after spine surgery. Chronic low back pain (CLBP) with Modic Changes (MCs) in the lumbar vertebrae, as observed on MRI, forms a specific subgroup. This study aims to investigate the potential influence of DM on CLBP with MCs.Methods This study involved 259 patients with CLBP accompanied MCs. We recorded the patient-reported outcomes (visual analogue scale (VAS), Oswestry Disability Index (ODI), and Roland-Morris Disability Questionnaire (RMDQ)) at baseline, 3, 6, and 12 months. Multivariable linear regression analyses were performed to determine predictors of patient-reported outcomes.Results 103 patients had DM. Patients with DM exhibited higher VAS (P< .05), ODI (P< .001), and RMDQ (P< .001) scores at 3, 6, and 12 months, while patients without DM experienced more significant improvements in the scores over time (P< .001). Patients with DM reported longer durations of physical exercise (P= .007). Additionally, patients without DM had a significantly higher patient satisfaction index (P< .001) and a lower prevalence of hypertension (P< .001). Notably, significant differences were observed in the distribution of MCs of lumbar vertebrae (P= .034) and Pfirrmann grades of intervertebral disc degeneration between two groups (P< .001).Conclusion Patients with DM demonstrated poorer patient-reported outcomes compared to those without DM in 1-year. DM emerged as an independent predictor of adverse patient-reported outcomes. It can be utilized to enhance the management and treatment of CLBP in patients with MCs. |
| Databáze: |
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