| Autor: |
Okuno, Yasuhisa, Plesner, Liselotte, Larsen, Thomas R., Gliemann, Jørgen |
| Zdroj: |
FEBS Letters; January 1986, Vol. 195 Issue: 1 p303-308, 6p |
| Abstrakt: |
Transport of the nonmetabolizable hexose analogue 3- O-methyl-D-glucose (3OMG) was measured in human polymorphonuclear leukocytes at 37° pH 7.4. 30MG at very low concentration (0.05 mM) equilibrated with the intracellular water with a rate constant of about 0.08 s −1. Transport of 3OMG in the presence of 20 μM cytochalasin B and transport of L-glucose were insignificant. Countertransport of 14C-labelled 3OMG was demonstrated. Exchange of 3OMG between the extracellular and intracellular water showed saturation with a Kmof about 4 mM. Thus, the transport of 3OMG is mediated almost exclusively by facilitated diffusion. |
| Databáze: |
Supplemental Index |
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