Mobilization of intracellular calcium by glucagon and cyclic AMP analogues in isolated rat hepatocytes

Autor: Mauger, Jean-Pierre, Claret, Michel
Zdroj: FEBS Letters; January 1986, Vol. 195 Issue: 1 p106-110, 5p
Abstrakt: Separate or combined addition of cyclic AMP-dependent and Ca 2+-linked hormones to isolated rat hepatocytes suspended in a low Ca 2+medium reduced the total cellular Ca. When the hormones were administered together, their effects were not additive. This suggests that both types of hormones mobilize Ca 2+from a common intracellular pool. In the presence of 1.8 mM extracellular Ca 2+, the Ca 2+influx counterbalanced or even exceeded the hormone-induced Ca 2+loss, depending on the ability of the hormones to stimulate the Ca 2+influx.
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