| Autor: |
Tomiya, Noboru, Watanabe, Kazuo, Awaya, Juichi, Kurono, Masayasu, Fujii, Setsuro |
| Zdroj: |
FEBS Letters; January 1985, Vol. 193 Issue: 1 p44-48, 5p |
| Abstrakt: |
Acyl-plasmin-streptokinase complex has advantages as a ‘site’ directed fibrinolytic agent with the active site protected from the plasma protease inhibitors. But, in clinical use, the fibrinolytic potential of this acylenzyme complex is modified or abolished by the presence of streptokinase antibodies in the patients. Therefore, better therapeutic agents are required. In this work, chemical modification of the acyl-plasmin-streptokinase complex with polyethylene glycol was found to result in marked resistance to neutralization with streptokinase antibodies. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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