| Autor: |
di Bello, Isabelle Cenci, Dorling, Peter, Fellows, Linda, Winchester, Bryan |
| Zdroj: |
FEBS Letters; January 1984, Vol. 176 Issue: 1 p61-64, 4p |
| Abstrakt: |
The glucuronic acid analogue of 1-deoxynojirimycin, 2( S)-carboxy-3( R), 4( R), 5( S)-trihydroxypiperidine, recently isolated from seeds of Baphia racemosa, is a novel specific inhibitor of human liver β-D-glucuronidase and α-L-iduronidase. No other glycosidases are inhibited. The inhibition of β-D-glucuronidase is competitive, with a Kiof 8 × 10 −5M and is pH-dependent. This inhibitor may be useful to induce a mucopolysaccharidosis or to investigate the function of microsomal β-D-glucoronidase. |
| Databáze: |
Supplemental Index |
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