| Autor: |
Abraham, David J., Sidebothom, Ramon, Winchester, Bryan G., Dorling, Peter R., Dell, Anne |
| Zdroj: |
FEBS Letters; January 1983, Vol. 163 Issue: 1 p110-113, 4p |
| Abstrakt: |
Rats, sheep and guinea pigs treated with swainsonine excrete ‘high mannose’ oligosaccharides in urine. The major rat and guinea pig oligosaccharide is (Man) 5GlcNAc whereas sheep excrete a mixture of oligosaccharides of composition (Man) 2–5GlcNAc 2and (Man) 3–5GlcNAc. The presence of these oligosaccharides suggests that Golgi α-D-mannosidase II as well as lysosomal α-D-mannosidase is inhibited by swainsonine resulting in storage of abnormally processed asparagine-linked glycans from glycoproteins. Altered glycoprotein processing appears to have little effect on the health of the intoxicated animal, but the accompanying lysosomal storage produces a disease state. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text