| Autor: |
Elford, Peter R., Meats, Judith E., Sharrard, R.Michael, Russell, R.Graham G. |
| Zdroj: |
FEBS Letters; January 1985, Vol. 179 Issue: 2 p247-251, 5p |
| Abstrakt: |
Human synovial explants in culture release material that stimulates the production of prostaglandin E 2(PGE 2) and several extracellular enzymes by human chondrocytes. Fractionation of conditioned medium by gel filtration revealed a protein of approx. 15 kDa, which in addition to stimulating production of PGE 2and plasminogen activator by human articular chondrocytes, possessed interleukin 1 activity and induced cartilage degradation. Further purification using iso-electric focussing again showed co-elution of these activities with a major p Iof 6.9 and a minor p Iof 5.1–5.3. This study indicated that human synovium releases a facor that is closely related to or identical with interleukin 1 and suggests that this protein may participate in cellular interactions that occur within the rheumatoid joint. |
| Databáze: |
Supplemental Index |
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