| Autor: |
Leno, Gregory H., Ledford, Barry E. |
| Zdroj: |
FEBS Letters; January 1990, Vol. 276 Issue: 1 p29-33, 5p |
| Abstrakt: |
Starvation of Mouse hepatoma cells for essential amino acids or glucose results in the mono-ADP-ribosylation of the 78 kDa glucose-regulated protein, GRP78. Here we show that the ADP-ribosylated and non-ADP-ribosylated forms of GRP78 are interconvertible during tryptophan starvation and refeeding. In addition, the ADP-ribosylation of GRP78 was shown to be reversible even during nutritional stress. The overexpressed pool of non-ADP-ribosylated GRP78 synthesized during tunicamycin treatment was available for ADP-ribosylation during subsequent amino acid starvation, especially in the absence of tunicamycin. The reversible ADP-ribosylation of GRP78 could be part of a metabolic control mechanism in operation during nutritional stress. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text