| Autor: |
Cheek, Timothy R., O'Sullivan, Antony J., Moreton, Roger B., Berridge, Michael J., Burgoyne, Robert D. |
| Zdroj: |
FEBS Letters; January 1989, Vol. 247 Issue: 2 p429-434, 6p |
| Abstrakt: |
The spatial distribution of the intracellular free Ca 2+(Ca 2+i) rise elicited by different stimuli in bovine adrenal chromaffin cells was examined in single fura-2-loaded cells. In response to the potent secretagogues nicotine and high K +, Ca 2+iwas initially localized exclusively to the entire subplasmalemmal area of the cell. In response to the ineffective secretagogues, methacholine and muscarine, the rise in Ca 2+ioriginated only in one pole of the cell and even at the peak of the response Ca 2+was still generally restricted to this same area of the cell. These results suggest that the triggering of exocytosis from these cells requires a specific spatial distribution of Ca 2+i. |
| Databáze: |
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