Specific inhibition of mitochondrial protein synthesis influences the amount of complex I in mitochondria of rat liver and Neurospora crassadirectly

Autor: van den Bogert, C., Holtrop, M., de Vries, H., Kroon, A.M.
Zdroj: FEBS Letters; January 1985, Vol. 192 Issue: 2 p225-229, 5p
Abstrakt: Specific inhibition of mitochondrial protein synthesis reduces the oxidation rate of NADH-linked substrates in rat liver as well as in Neurospora crassamitochondria. The present study shows that this is due to the fact that inhibition of mitochondrial protein synthesis leads to a decrease of the concentration of active complex I. Therefore, these results demonstrate that at least one of the genes for the subunits of complex I is localized on mitochondrial DNA.
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