| Autor: |
Esnard, F., Gutman, N., El Moujahed, A., Gauthier, F. |
| Zdroj: |
FEBS Letters; January 1985, Vol. 182 Issue: 1 p125-129, 5p |
| Abstrakt: |
The overall mechanism of interaction with proteinases of α 1-inhibitor 3, a plasma proteinase inhibitor so far specific to the rat, has been shown to be closely similar to that described for α-macroglobulins. This mechanism includes: (i) the cleavage of at least one susceptible peptidic bond which leads to structural changes in the molecule, (ii) The cleavage of a putative thiol ester bond in another site of the molecule which permits the covalent linkage of the enzyme. Moreover, fragmentation of α 1-inhibitor 3upon heating as observed for α-macroglobulin quarter subunits has been demonstrated. The question is raised of the presence of such a molecule in rat plasma in addition to two α-macroglobulin species, all of these proteinase inhibitors being antigenically unrelated. |
| Databáze: |
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