Abolishment of inhibitory effects of 3'-deazaadenosine on Superoxide generation of guinea pig phagocytes by pre-exposure to phorbol myristate acetate

Autor: Yagawa, Katsuro, Nakanishi, Masayuki, Hayashi, Shinichiro, Kaku, Mariko, Ichinose, Yukito, Itoh, Tokuo, Tomoda, Akio, Yoneyama, Yoshimasa, Shigematsu, Nobuaki
Zdroj: FEBS Letters; January 1986, Vol. 201 Issue: 2 p287-290, 4p
Abstrakt: Superoxide generation by guinea pig macrophages and polymorphonuclear leukocytes induced by wheat germ agglutinin, immune complexes or formyl-methionyl-leucyl-phenylalanine was inhibited considerably by 3'-deazaadenosine. The pre-exposure of the 3'-dezazaadenosine-treated cells to a small amount of phorbol myristate acetate abolished the inhibitory effect of 3'-deazaadenosine on the generation of Superoxide.
Databáze: Supplemental Index