| Autor: |
Leys, K., Morice, A.H., Madonna, O., Sever, P.S. |
| Zdroj: |
FEBS Letters; January 1986, Vol. 199 Issue: 2 p198-202, 5p |
| Abstrakt: |
Localisation and pharmacological properties of the VIP receptor in human lung sections are described. The receptor density determined by saturation analysis using 125I-VIP is approx. 100 fmolmgprotein, with a kdof approx. 600 pM. Inhibition of 125I-VIP binding with VIP and related peptides gives a rank order of potency: VIP /s> peptide histidine methionine /s> secretin. Light microscope autoradiography reveals specific VIP binding sites, with a high density over the pulmonary artery smooth muscle and the alveolar walls and with a lower density over the bronchial epithelium. |
| Databáze: |
Supplemental Index |
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