Activation of phospho enolpyruvate-dependent protein kinase by cytidine 5′-triphosphate in rat skeletal muscle

Autor: Mattoo, Roshan L., Waygood, E.Bruce, Khandelwal, Ramji L.
Zdroj: FEBS Letters; January 1984, Vol. 165 Issue: 1 p117-120, 4p
Abstrakt: The effects of nucleotides on phospho enolpyruvate-dependent protein kinase in rat skeletal muscle were examined. Various ribonucleotide triphosphates were tested and the protein kinase reaction was maximally activated by cytidine 5′-triphosphate followed by uridine 5′-triphosphate and guanosine 5′-triphosphate. No activation by adenosine 5′-triphosphate was observed. Cytidine 5′-diphosphate also activated the reaction but to a significantly lesser extent. Cytidine 5′-monophosphate and cyclic cytidine 3′,5′-monophosphate showed no effect whereas cytidine was slightly inhibitory.
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