| Autor: |
Brass, Eric P., Garrity, Maureen J., Robertson, R.Paul |
| Zdroj: |
FEBS Letters; January 1984, Vol. 169 Issue: 2 p293-296, 4p |
| Abstrakt: |
The effect of E-series prostaglandins (PGE) on hepatic glucose metabolism is controversial. This study uses isolated rat hepatocytes and exogenously added PGE analogs or frequent native PGE additions (to compensate for hepatic PGE degradation) to define PGE's effect on hepatic glycogenolysis. 16,16-Dimethyl PGE 2, 15( S),15-methyl PGE 2, PGE 1and PGE 2all inhibit glucagon-stimulated glycogenolysis. It is concluded that E-series prostaglandins can act directly on the liver to inhibit glycogenolysis. |
| Databáze: |
Supplemental Index |
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