Enhancement of Ca 2+-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells

Autor: Brocklehurst, Keith W., Pollard, Harvey B.
Zdroj: FEBS Letters; January 1985, Vol. 183 Issue: 1 p107-110, 4p
Abstrakt: The phorbol ester, 4β-phorbol 12-myristate acetate (TPA), increased the extent of catecholamine release induced by Ca 2+, without affecting the basal release response in digitonin-permeabilized chromaffin cells. This finding is consistent with the hypothesis that protein kinase C has a role to play in stimulus-secretion coupling in the bovine adrenal medullary chromaffin cell.
Databáze: Supplemental Index