| Autor: |
Giorgi, Dominique, Laval, Monique, Pardo, Daniel |
| Zdroj: |
FEBS Letters; January 1983, Vol. 162 Issue: 2 p374-378, 5p |
| Abstrakt: |
In Drosophila melanogasterthe rudimentary locus encodes for a multifunctional protein catalyzing the first three enzymatic activities of pyrimidine biosynthesis. Cell lines were selected which were resistant to PALA ( N-(phosphonoacetyl)-L-aspartate), a specific inhibitor of aspartate transcarbamylase, the second enzyme of this pathway. In a cell line where the enzyme production is increased 5 times, Southern blot analyses show that the rudimentary gene and surrounding regions are amplified about 5 times. In this case gene amplification could therefore account for the observed enzyme overproduction. |
| Databáze: |
Supplemental Index |
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