| Autor: |
Matsui, Hisao, Wada, Osamu, Ushijima, Yoshio, Akuzawa, Takafumi |
| Zdroj: |
FEBS Letters; January 1983, Vol. 164 Issue: 2 p251-254, 4p |
| Abstrakt: |
Treatment of human neutrophils with triphenyltin chloride (TPTCl)-inhibited superoxide (O −2) production stimulated with phorbol myristate acetate (PMA). TPTCl was more potent as inhibitor of O −2production than other phenyltin compounds. The O −2production by the xanthine oxidase—acetaldehyde system was not inhibited by TPTCl. This finding indicates that TPTCl does not itself react with O −2. Furthermore, TPTCl did not influence the isolated NADPH oxidase at all, though O −2production of neutrophils stimulated with PMA in the presence of TPTCl was inhibited. These results indicate that TPTCl inhibits the activation process of the O −2generating system. |
| Databáze: |
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