A rapid-kinetic study of the class C β-lactamase of Enterobacter cloacae908R

Autor: Monnaie, Didier, Virden, Richard, Frère, Jean-Marie
Zdroj: FEBS Letters; January 1992, Vol. 306 Issue: 2 p108-112, 5p
Abstrakt: The individual rate constants for acylation and deacylation ( k2and k3, respectively) of the class C β-lactamase of Enterobacter cloacae908R by ampicillin and carbenicillin have been determined. For several other β-lactams, the value of k2was too high to be determined and the k2/ k3ratio could be larger than 10,000. Branched pathways were also shown to occur with several penicillins and cephalosporins.
Databáze: Supplemental Index