| Autor: |
de Waal, Anthony, Gomes, Ana Vaz, Mensink, Anne, Grootegoed, J.Anton, Westerhoff, Hans V. |
| Zdroj: |
FEBS Letters; January 1991, Vol. 293 Issue: 1 p219-223, 5p |
| Abstrakt: |
The hypothesis was tested that the magainin peptides, known to compromise bacterial and mitochondrial energetics, are highly active against spermatozoa. A mixture of magainin A and PGLa (1:1) caused a 50% reduction in motility of hamstet spermatozoa at 4 μg/ml total peptide concentration, All motility was lost at 8 μ/ml. At this concentration, respiratory control was released and respiration in the presence of uncoupler was inhibited. Uptake or the lipophilic cation tetraphenyl phosphonium was largely abolished by addition or magainin A and PGLa at this concentration, indicative of a decrease in the mitochondrial membrane potential. Magainin A and PGLa showed synergism with respect to release of respiratory control. |
| Databáze: |
Supplemental Index |
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