| Autor: |
Galisteo, Alberto, Zaher, Houda, Lopez-Menchero, Jorge R., Gonzalez-Coloma, Azucena, Andres, Maria Fe de, Moral, José F. Quílez del, Barrero, Alejandro F. |
| Zdroj: |
Natural Product Communications; April 2024, Vol. 19 Issue: 4 |
| Abstrakt: |
Objectives:The potential forestry use of Juniperus phoeniceaand Juniperus thuriferapruning woods is studied by analyzing the composition of the woods and testing the biological activities of the corresponding components with the ultimate target of finding new biopesticides. Methods:The air-dried wood from each plant was crushed and subjected to hydrodistillation, and the residue was extracted with a Soxhlet apparatus using different solvents. The corresponding extracts were fractionated, and their composition were studied by gas chromatography-mass spectrometry and nuclear magnetic resonance techniques. The ixodicidal and antifungal activities of the different samples obtained were evaluated. Results:The fraction oxygenated of the essential oil from both J. thurifera(cedrol >60%) and J. phoeniceashows a remarkable bioactivity as antitick with EC50values of 3.4 μg/mg and 10 μg/mg, respectively. Cedrol and methyl hinokiate, present in the hexane extract J. thurifera, show a potent antifungal effect against Aspergillus nigerwith EC50values of 45.99 and 52.23 μg/mL, respectively. Conclusions:Pruning woods from these species proved to be renewable and easily accessible sources of bioactive natural products such as cedrol, thujopsene, nootkatone, and totarol. |
| Databáze: |
Supplemental Index |
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