Antrodia cinnamomeaextract alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting the mTOR pathway

Autor: Lan, Ying-Wei, Chen, Chia-En, Huang, Tsung-Teng, Huang, Tse-Hung, Chen, Chuan-Mu, Chong, Kowit-Yu
Zdroj: Biomedical Journal; December 2024, Vol. 47 Issue: 6
Abstrakt: Pulmonary fibrosis is a progressive diffuse parenchymal lung disorder with a high mortality rate. Studies have indicated that injured lung tissues release various pro-inflammatory factors, and produce a large amount of nitric oxide. There is also accumulation of collagen and oxidative stress-induced injury, collectively leading to pulmonary fibrosis. Antrodia cinnamomeais an endemic fungal growth in Taiwan, and its fermented extracts exert anti-inflammatory effects to alleviate liver damages. Hence, we hypothesized and tested the feasibility of using A. cinnamomeaextracts for treatment of pulmonary fibrosis.
Databáze: Supplemental Index