| Autor: |
Abakan, İlkkan, Özbilenler, Cahit, Ustürk, Selma, Kerküklü, Namık Refik, Gulcan, Hayrettin Ozan, Güran, Mümtaz, Gazi, Mustafa |
| Zdroj: |
Journal of Water Chemistry and Technology; April 2024, Vol. 46 Issue: 2 p157-168, 12p |
| Abstrakt: |
Abstract: In this study ciprofloxacin-loaded carboxymethyl cellulose (CMC)/ polyvinyl alcohol (PVA) cryogel systems were prepared by using low molecular weight PVA. The high degree of segmental mobility of PVA molecules makes them more prone to form CMC/PVA cryogels via hydrogen bondings with CMC. Physically crosslinked gels were characterised by using Fourier-transform infrared spectroscopy (FTIR). Swelling results have shown that low molecular weight PVA had a fast-swelling rate and this can explain the fast release of ciprofloxacin within 30 min from CMC/PVA cryogels during release studies. Release of ciprofloxacin from the CMC/PVA cryogel system was the best fit to first-order release model with R2= 0.9980. It was found that the release exponent is lower than 0.45 and it is a good indication of quasi-Fickian diffusion, which means that ciprofloxacin can be released without swelling of the cryogel. Ciprofloxacin was found to have even better antimicrobial activity against E. colithan positive control as having a higher inhibition zone. In addition, CMC/PVA cryogels can be used for water treatment application to remove Methylene Blue (MB) dye from water and this was supported by adsorption kinetics and isotherm studies. |
| Databáze: |
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