| Autor: |
Balkrishna, Acharya, Mishra, Shalini, Singh, Shalini, Rana, Maneesha, Arya, Vedpriya, Mishra, Rajesh, Rajput, Satyendra Kumar, Kumar, Ashwani |
| Zdroj: |
The Natural Products Journal; 2024, Vol. 14 Issue: 6 |
| Abstrakt: |
Diabetes mellitus is a chronic disease affecting more than 300 million people worldwide. Even after advances in medicine, we are still away from a permanent solution to this problem. Longterm use of currently available treatments are associated with adverse effects ranging from cardiovascular conditions, renal disorders, liver ailments, and weight gain. Subsequently, a significant diabetic population seeks herbal medicines that are said to control blood sugar levels. Several plants have been explored in this context; one such plant is Withania coagulansDunal., which is known for the hypoglycemic property due to its fruits. Different plant parts and bioactive components like withanolides exhibited anti-diabetic activity in type 2 diabetes models in vivoand in vitro. However, clinical studies are limited and more research is warranted. Bioactive composition of W. coagulansinclude Withanolide J, F; Coagulin C, E, L; Ajugin E, Withaperuvin C and others. Bioavailability of Withaferin A from W. coagulanswas enhanced by co-administration of Piperine. Herbal quality control and commercialization aspects of W. coagulansare also highlighted. W. coagulanscan be employed in managing type 2 diabetes mellitus after detailed follow-up studies. |
| Databáze: |
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