| Autor: |
Atak, Mehtap, Sevim Nalkiran, Hatice, Bostan, Mehmet, Uydu, Huseyin Avni |
| Zdroj: |
Acta cardiologica; February 2024, Vol. 79 Issue: 2 p159-166, 8p |
| Abstrakt: |
AbstractBackgroundControversial effect of sortilin on lipoprotein metabolism in the development of atherosclerosis reveals the need for more extensive researchObjectivesThe aim of this study was to investigate the association between Sort1gene expression and lipids, lipoprotein subfractions, and inflammation in CAD.MethodsThe study population included 162 subjects with CAD and 49 healthy individuals. The Sort1gene expression level was determined by qRT-PCR using Human Sortilin TaqMan Gene Expression Assays. Lipoprotein subclasses were analysed by the Lipoprint system. Serum levels of apolipoprotein and CRP were measured by autoanalyzer.ResultsSort1gene expression and atherogenic subfraction (SdLDL) levels were significantly higher (p < 0.001) while atheroprotective subfraction (LbLDL) was lower in the subjects with CAD (p < 0.050). Also, increased Sort1gene expression levels were observed in those with higher CRP values.ConclusionsOur findings reveal that the high Sort1gene expression has a prominent linear relationship with both the atherogenic LDL phenotype and proinflammation, thereby might contribute to the occurrence of CAD. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
