| Autor: |
Bosio, Guillaume, Destrempes, François, Roy Cardinal, Marie‐Hélène, Cloutier, Guy |
| Zdroj: |
Journal of Ultrasound in Medicine; May 2024, Vol. 43 Issue: 5 p829-840, 12p |
| Abstrakt: |
The consequences associated with blood clots are numerous and are responsible for many deaths worldwide. The assessment of treatment efficacy is necessary for patient follow‐up and to detect treatment‐resistant patients. The aim of this study was to characterize the effect of treatment on blood clots in vitro using quantitative ultrasound parameters. Blood from 10 pigs was collected to form three clots per pig in gelatin phantoms. Clots were subjected to 1) no treatment, 2) rt‐PA (recombinant tissue plasminogen activator) treatment after 20 minutes of clotting, and 3) rt‐PA treatment after 60 minutes of clotting. Clots were weighted before and after the experiment to assess the treatment effect by the mass loss. The clot kinetics was studied over 100 minutes using elastography (Young's modulus, shear wave dispersion, and shear wave attenuation). Homodyne K‐distribution (HKD) parameters derived from speckle statistics were also studied during clot formation and dissolving (diffuse‐to‐total signal power ratio and intensity parameters). Treated clots loosed significantly more mass than non‐treated ones (P< .005). A significant increase in Young's modulus was observed over time (P< .001), and significant reductions were seen for treated clots at 20 or 60 minutes compared with untreated ones (P< .001). The shear wave dispersion differed for treated clots at 60 minutes versus no treatments (P< .001). The shear wave attenuation decreased over time (P< .001), and was different for clots treated at 20 minutes versus no treatments (P< .031). The HKD intensity parameter varied over time (P< .032), and was lower for clots treated at 20 and 60 minutes than those untreated (P< .001 and P< .02). The effect of rt‐PA treatment could be confirmed by a decrease in Young's modulus and HKD intensity parameter. The shear wave dispersion and shear wave attenuation were sensitive to late and early treatments, respectively. The Young's modulus, shear wave attenuation, and HKD intensity parameter varied over time despite treatment. |
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