| Autor: |
Ladu, Adama Isah, Jeffery, Caroline, Farate, Abubakar, Farouk, Abubakar G, Abulfathi, Fatima M, Adekile, Adekunle, Bates, Imelda |
| Zdroj: |
Ultrasound : Journal of the British Medical Ultrasound Society; 20240101, Issue: Preprints |
| Abstrakt: |
Background: Ultrasonography is an established and reliable method for assessing the spleen. Because of variation due to genetic and other environmental factors including malaria endemicity, interpretation of spleen sizes requires a knowledge of the normal reference range for a given population. This study aimed to identify spleen size reference ranges across age groups of healthy controls to serve as a baseline to assess changes in spleen size in patients with sickle cell disease.Methods: Using a cross-sectional study design, spleen size was measured in healthy people of different age groups and steady-state sickle cell disease patients (children and adults) using abdominal ultrasonography. Using the age-group-specific reference values obtained from the controls, spleens were classified into small, normal size or enlarged among the sickle cell disease patients.Results: The study consisted of 109 (34.8%) healthy controls and 204 (65.2%) steady-state sickle cell disease patients. The spleen was visualised in all the controls (n= 109) and in 107 (52.4%) sickle cell disease patients. Using cut-off values for spleen length among the controls across age groups (< 5 years (5.0–7.0 cm); 5–9 years (5.5–8.5 cm); 10–14 years (6.0–11.0 cm) and ⩾ 15 years (7.0–12.5 cm)), spleen size was classified as small (n= 18/204; 8.87%), normal (n= 68/204; 33.3%) and enlarged (n= 21/204; 10.3%) among the sickle cell disease patients.Conclusion: Model-based age-group reference ranges and percentile curves for splenic dimensions based on ultrasonography among normal controls in North-Eastern Nigeria were established and may be of value in assessing spleen sizes among sickle cell disease patients living in malaria-endemic regions of Africa. |
| Databáze: |
Supplemental Index |
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