| Autor: |
Van der Borght, Katrien, Brimnes, Jens, Haspeslagh, Eline, Brand, Stephanie, Neyt, Katrijn, Gupta, Shashank, Peter Hell Knudsen, Niels, Hammad, Hamida, Andersen, Peter S., Lambrecht, Bart N. |
| Zdroj: |
Mucosal immunology; 20240101, Issue: Preprints |
| Abstrakt: |
•Prophylactic SLIT reduces HDM-driven allergic airway inflammation and airway hyperresponsiveness.•Experimental SLIT is reproducible over time and in different labs and animal facilities.•SLIT decreases the Th2 response and increases regulatory and Th17 responses.•Sublingually administered Der p 1 protein is presented to specific CD4+ T-cells in the cervical LNs.•Migratory cDC2 -not cDC1- activate GATA-3+and RORgt+cells also expressing FoxP3+.•SLIT increases Derp1-specific Tregs in the lung and blocks Derp1-specific Th2 cells in lung and mLN.•Prophylactic SLIT partly depends on FoxP3+ Tregs |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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