| Autor: |
Li, Jiachen, Sun, Feng, Zhu, Danxue, Hou, Yuke, Cheng, Gong, Wang, Ping, Jin, Xu, Zhou, Wenyan, Sun, Xiaolin, Li, Zhanguo, Liu, Tian |
| Zdroj: |
Arthritis Research & Therapy (formerly Arthritis Research); December 2024, Vol. 26 Issue: 1 |
| Abstrakt: |
Background: Autoimmune responses have been suggested to involvement in patients with Behcet’s syndrome (BS). There has been growing attention towards the roles of cutaneous lymphocyte antigen (CLA)+regular T cells (Tregs) in autoimmune diseases. The role of CLA+Tregs in BS is still uncertain. This study aims to clarify the impact of CLA+Tregs on BS. Methods: We collected peripheral blood from a total of 107 patients with BS and 114 healthy controls (HCs). The number of CLA+Tregs, natural killer (NK) cells, B cells, and several subtypes of CD4+T cells were detected using flow cytometry and compared between patients and HCs. Results: The absolute number and proportion of CLA+Tregs among CD4+T lymphocytes and CD4+Tregs were lower in patients with BS than in HCs. CLA+Tregs were positively related with NK cells (r= 0.500, P< 0.001) and B cells (r= 0.470, P< 0.001) and negatively related with effector T cells (r=-0.402, P< 0.001) in patients with BS. Patients with BS and arterial aneurysms had CLA+Treg cell deficiency. A decreased proportion of CLA+Tregs was associated with arterial aneurysms in patients with BS. The proportion of CLA+Tregs in patients with BS increased with corticosteroids and immunosuppressants. Conclusion: CLA+Tregs decrease in association with arterial aneurysm in patients with BS. CLA+Tregs may be a predictor of response to BS treatment. |
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