Sex, Body Mass Index, and APOE4Increase Plasma Phospholipid–Eicosapentaenoic Acid Response During an ω-3 Fatty Acid Supplementation: A Secondary Analysis

Autor: Loukil, Insaf, Aguilera, Ester Cisneros, Vachon, Annick, Léveillé, Pauline, Plourde, Mélanie
Zdroj: The Journal of Nutrition; 20240101, Issue: Preprints
Abstrakt: The brain is concentrated with omega (ω)-3 (n–3) fatty acids (FAs), and these FAs must come from the plasma pool. The 2 main ω-3 FAs, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), must be in the form of nonesterified fatty acid (NEFA) or esterified within phospholipids (PLs) to reach the brain. We hypothesized that the plasma concentrations of these ω-3 FAs can be modulated by sex, body mass index (BMI, kg/m2), age, and the presence of the apolipoprotein (APO) E-ε4 allele in response to the supplementation.
Databáze: Supplemental Index