| Autor: |
Bahri, Sana, Abdennabi, Raed, Chaker, Asma, Nahdi, Afef, Elgheryeni, Amine, Mlika, Mona, Jameleddine, Saloua |
| Zdroj: |
Biomarkers; February 2024, Vol. 29 Issue: 2 p45-54, 10p |
| Abstrakt: |
AbstractObjectiveIdiopathic pulmonary fibrosis (IPF) is the most serious form of interstitial lung disease. We aimed to investigate the effect of Phœnix dactylifera, L.seed oil (DSO) on a murine model of IPF induced by bleomycin (BLM).MethodsMale Wistar rats were treated with a single intra-tracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of DSO (75, 150 and 300 mg/kg) for 4 weeks.ResultsOur phytochemical results showed that DSO has an important antioxidant activity with a high content of polyphenols and flavonoids. High-Performance Liquid Chromatography (HPLC) and Gas chromatography/mass spectrometry (GC-MS) analysis revealed a high amount of oleic and lauric acids and a large quantity of vitamins. Histological examination showed a significant reduction in fibrosis score and collagen bands in the group of rats treated with 75 mg/kg of DSO compared to the BLM group. DSO (75 mg/kg) reversed also the increase in catalase and malondialdehyde (MDA) levels while higher doses (150 and 300 mg/kg) are ineffective against the deleterious effects of BLM. We revealed also that DSO has no renal or hepatic cytotoxic effects.ConclusionDSO can play antioxidant and antifibrotic effects on rat models of pulmonary fibrosis at the lowest dose administered. |
| Databáze: |
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