| Autor: |
Tan-Garcia, Alfonso, Lee, York Tien, Kuick, Chik Hong, Soh, Shui Yen, Chang, Kenneth Tou-En, Merchant, Khurshid |
| Zdroj: |
Pediatric and Developmental Pathology; March 2024, Vol. 27 Issue: 2 p187-192, 6p |
| Abstrakt: |
The differential diagnosis for neonatal primary lung masses includes developmental anomalies and congenital lung tumors. Fetal lung interstitial tumor (FLIT) is a rare benign mesenchymal lesion which presents either antenatally or within the first 3 months of age. FLIT is a circumscribed solid-cystic mass which histologically resembles the fetal lung during the canalicular stage at 20–24 weeks of gestation. It is composed of immature mesenchymal cells expanding the interstitium and irregular airspace-like structures. Of all published cases, only 1 identified an α2-macroglobulin (A2M)::anaplastic lymphoma kinase (ALK) fusion and all cases underwent surgical resection in the neonatal or infancy period. We present the second case of FLIT with an A2M::ALKfusion diagnosed postnatally in a neonate which partially regressed spontaneously during conservative management with interim resection at 39 months of age, and provide a review of the literature. |
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