| Autor: |
Coles née Huth, L. Susanne, Threlfall, Terry L., Hughes, David S. |
| Zdroj: |
Crystal Growth & Design; March 2024, Vol. 24 Issue: 6 p2552-2566, 15p |
| Abstrakt: |
The dependence of crystal structure assembly on molecular changes is studied for a series of monosubstituted acetanilide compounds. A library of 81 crystal structures is obtained from the Cambridge Structural Database, structural similarities are determined, and energetic preferences are assessed. Two dominant amide–amide hydrogen bond geometries and a molecular stack are frequently observed especially in the para-acetanilide subgroup. In all cases, the amide functional group has a greater effect on the chain geometry and resultant crystal packing than the phenyl substituent. The study concludes with a short review of the polymorphism of paracetamol and suggests an alternative concept for overcoming the compaction issues currently encountered in the manufacture of the oral dosage form. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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