| Autor: |
O’Halloran, Charlotte, Gilleece, Yvonne, Leung, Suki, Canuto, Veronica, McAlpine, Connor, Ross, Sophie, Norcross, Claire, Gaffney, Stuart, Siani, Nipur, Hickey, William, Moore, Adam, Rajkovic-Hooley, Olivera, Milinkovic, Ana |
| Zdroj: |
International Journal of STD & AIDS; March 2024, Vol. 35 Issue: 3 p206-216, 11p |
| Abstrakt: |
Background Doravirine is a non-nucleoside reverse transcriptase inhibitor recommended for the treatment of virologically suppressed and treatment naïve people living with HIV. The DRIVE-REAL study aimed to describe the characteristics, treatment patterns, and virological outcomes of doravirine users in a real-world cohort in the UK.Methods A retrospective, observational, multi-centre chart review was conducted for 300 adults living with HIV initiating doravirine-containing antiretroviral therapy.Results At baseline 83% of individuals were male, 45% aged ≥50 years, 65% white ethnicity. Median time since HIV diagnosis was 12 years. 96% were antiretroviral therapy-experienced, 87% had a HIV viral load <50 copies/ml, and 15% had resistance to at least one antiretroviral drug. 66% had comorbidities, most commonly depression (26%), and 70% were taking at least one co-medication. At six months, 94% (n= 283/300) were still receiving doravirine. Viral load data were available for n= 266/300 individuals and 95% (n= 253/266) had viral load <50 copies/ml.Conclusions Individuals initiating doravirine in this cohort are predominantly treatment-experienced white middle-aged males, with a high frequency of comorbidities and co-medication. The majority of individuals at 6 months remained on doravirine and maintained or achieved HIV viral suppression. This study provides epidemiologic characteristics that can inform clinical care and subsequent hypothesis-testing studies. |
| Databáze: |
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