| Autor: |
Lee, Kevin, Dixon, Alistair K., Rowe, Iain C.M., Ashford, Michael L.J., Richardson, Peter J. |
| Zdroj: |
British Journal of Pharmacology; June 1995, Vol. 115 Issue: 3 p385-388, 4p |
| Abstrakt: |
We examined whether ATP‐sensitive potassium (KATP) channels are present on presynaptic terminals of the rat motor cortex, an area of the CNS exhibiting a high density of sulphonylurea binding. A novel fused nerve terminal preparation was developed which produced structures amenable to patch clamp methods. In inside‐out recordings a K+channel was observed which possessed all the major features of the Type 1 KATPchannel, including sensitivity to ATP and the antidiabetic sulphonylureas. |
| Databáze: |
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