| Autor: |
Klein, Peter D., Malaty, Hoda M., Czinn, Steven J., Emmons, Steven J., Martin, Robert F., Graham, David Y. |
| Zdroj: |
Journal of Pediatric Gastroenterology & Nutrition; September 1999, Vol. 29 Issue: 3 p297-301, 5p |
| Abstrakt: |
The 13C‐urea breath test detects the presence of Helicobacter pylorifrom an enrichment of breath 13CO2, which, in turn, is critically dependent on the amount of dilution by endogenous CO2production. The production of CO2differs according to age (adults > children), sex (male > female) weight, and height. The cutoff value of 2.4 Δ‰ (delta over baseline, DOB) for the 13C‐urea breath test, defined in adults, does not take into account actual CO2production. Therefore, this cutoff value (2.4 Δ‰) may or may not be appropriate for children. The purpose of this study was to determine a cutoff value that would provide accurate results in pediatric patients, independent of their differences in anthropometric parameters. Estimates of CO2production were combined with DOB values to calculate the host‐dependent urea hydrolysis rate. Calculated as urea hydrolysis rate, the cutoff range for adults was 10.4 to 10.9 µg/min. Individual ranges were concentric (men, 9.6‐10.9 µg/min; women, 8.5‐12.2 µg/min). Results in studies of 312 children show that a urea hydrolysis rate of more than 10 µg/min may also be appropriate to predict H. pyloriinfection. Calculating 13C‐urea breath test values as urea hydrolysis rate removes the effect of individual anthropometric differences on test outcome and provides a single cutoff value for pediatric patients of all ages. |
| Databáze: |
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