| Autor: |
Kamila, Rahmadian Kahfi Zulfa, Sururi, Ahmad Misbakhus, Arumsari, Maharani Dyah, Hendrata, Excelino, Wibowo, Dhea Mutiara Fernanda, Fajriyah, Luluatul, Rahayu, Dwi Anggorowati |
| Zdroj: |
Thalassas: An International Journal of Marine Sciences; June 2024, Vol. 40 Issue: 2 p857-868, 12p |
| Abstrakt: |
Blood Cockle (A. nodifera) have great potential for development, especially in the health sector. One of its essential components are fatty acids, which show potential as antihypertensive agents. This study aims to evaluate the potential of fatty acids in Blood Cockle (A. nodifera) as antihypertensive drugs through an in-silico approach using molecular docking method. The stages of this research include extraction, GC–MS analysis, molecular docking analysis, and ADME analysis. The study used angiotensin converting enzyme (ACE) as the target protein and ligand compounds derived from fatty acid isolates and the control drug captopril for comparison. The initial stage includes protein and ligand preparation, molecular docking and visualization. The potential compounds are then evaluated with Lipinski’s rule. The results showed that 5,8,11,14,17-Eicosapentaenoic acid have potential as ACE inhibitors, thus showing potential as antihypertensive drugs. More research is needed, including in vitro and in vivo testing, to optimize the medical potential of Blood Cockle (A. nodifera). |
| Databáze: |
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