| Autor: |
Vorobyova, Victoria, Skiba, Margarita, Khrokalo, Liudmyla, Vasyliev, Georgii |
| Zdroj: |
Chemistry Africa; 20240101, Issue: Preprints p1-12, 12p |
| Abstrakt: |
In the current study we used the grape pomace extract (GPE) based on deep eutectic solvent (DES) as reducing and capping agent for synthesizing of small (< 10 nm) gold nanoparticles. Organic compounds were extracted with L-proline/Lactic acid-based deep eutectic solvent. The synthesized AuNPs by DES-based GPE were characterized using UV–visible spectrophotometry, Fourier transform infrared (FTIR) spectrophotometry, scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) spectrometry. UV–visible absorbance spectral value at 423 nm confirmed the formation of AuNPs. The FTIR analysis revealed that carbonyl and hydroxyl groups of grape pomace extract were involved in reducing and capping of the DES grape pomace extract—AuNPs. The SEM analysis revealed that the synthesized gold nanoparticles were irregularly spherical with diameters ranging between 5 and 7 nm. The formation of gold nanoparticles was further confirmed by the EDX spectrum which revealed signals from Au (1,7–2,4 keV). The obtained DES-GPE-based gold nanoparticles displayed significant antibacterial activities against E. coli, B. subtilis, antifungal effect against Candida albicansyeast, and showed phytotoxicity influence in a concentration-dependent manner. The antibacterial activity of obtained DES-GPE-based gold nanoparticles against Bacillus subtiliswas the strongest. Mitotic index estimated by A. cepacytotoxicity method showed that AuNPs had negligible cytotoxic effects. |
| Databáze: |
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