Three-Component, Stereoselective Palladium-Catalyzed Synthesis of Functionalized Bicyclopentanoids

Autor: Hulin, B., Newton, L. S., Cabral, S., Walker, A. J., Bordner, J.
Zdroj: Organic Letters; November 2004, Vol. 6 Issue: 23 p4343-4345, 3p
Abstrakt: 1,5-Cyclooctadiene can be stereoselectively transformed into a substituted bicyclo[3.3.0]octane ring system under palladium catalysis with concomitant formation of three carbon−carbon bonds. Reaction with an aryl iodide or triflate and malonate gives an exo-endo product, while the reaction with a malonate in the presence of oxygen affords a bis-endo adduct.
Databáze: Supplemental Index