Practical Synthesis of 1-Aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo Amide−Epoxide Cyclization

Autor:	Powell, N. A., Ciske, F. L., Clay, E. C., Cody, W. L., Downing, D. M., Blazecka, P. G., Holsworth, D. D., Edmunds, J. J.
Zdroj:	Organic Letters; October 2004, Vol. 6 Issue: 22 p4069-4072, 4p
Abstrakt:	Chiral 1-aryl-6-(hydroxymethyl)-2-ketopiperazines can be prepared via an operationally simple, 6-exo epoxide ring-opening cyclization to form the ketopiperazine C6−N1 bond in high yields and with excellent enantiomeric purity.
Databáze:	Supplemental Index
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