Novel lateral flow assay for point-of-care detection of Neisseria gonorrhoeaeinfection in syndromic management settings: a cross-sectional performance evaluation

Autor: Peters, Remco P H, Klausner, Jeffrey D, Mazzola, Laura, Mdingi, Mandisa M, Jung, Hyunsul, Gigi, Ranjana M S, Piton, Jeremie, Daniels, Joseph, de Vos, Lindsey, Adamson, Paul C, Gleeson, Birgitta, Ferreyra, Cecilia
Zdroj: The Lancet; February 2024, Vol. 403 Issue: 10427 p657-664, 8p
Abstrakt: A rapid and affordable point-of-care test is a priority for Neisseria gonorrhoeaecontrol. WHO and Foundation for Innovative New Diagnostics (FIND) have a target product profile for a non-molecular N gonorrhoeaerapid point-of-care test that requires a clinical sensitivity of greater than 80% and a specificity over 95% to be considered useful in syndromic management; test turnaround time should be 30 min or under, and the test should cost less than US$3. A novel lateral flow assay (LFA) was developed to achieve that profile.
Databáze: Supplemental Index